Novel Arabidopsis microtubule-associated proteins track growing microtubule plus ends
نویسندگان
چکیده
منابع مشابه
Actin–microtubule coordination at growing microtubule ends
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin ar...
متن کاملPlus-End-Tracking Proteins and Their Interactions at Microtubule Ends
Microtubules are cytoskeletal elements that are essential for a large number of intracellular processes, including mitosis, cell differentiation and migration, and vesicle transport. In many cells, the microtubule network is organized in a radial manner, with one end of a microtubule (the minus end) embedded near the nucleus and the other end (the plus end) exploring cytoplasmic space, switchin...
متن کاملEBs clip CLIPs to growing microtubule ends
Proteins that track growing microtubule (MT) ends are important for many aspects of intracellular MT function, but the mechanism by which these +TIPs accumulate at MT ends has been the subject of a long-standing controversy. In this issue, Bieling et al. (Bieling, P., S. Kandels-Lewis, I.A. Telley, J. van Dijk, C. Janke, and T. Surrey. 2008. J. Cell Biol. 183:1223-1233) reconstitute plus end tr...
متن کاملOrganization and dynamics of growing microtubule plus ends during early mitosis.
A stable cell line expressing EB1-green fluorescent protein was used to image growing microtubule plus ends at the G(2)/M transition. By late prophase growing ends no longer extend to the cell periphery and were not uniformly distributed around each centrosome. Growing ends were much more abundant in the area surrounding the nuclear envelope, and microtubules growing around the nucleus were 1.5...
متن کاملTubulin tyrosination is required for the recruitment of CAP-Gly microtubule plus-end- tracking proteins at microtubule ends
Tubulin-tyrosine-ligase (TTL), the enzyme which catalyzes the addition of a C-terminal tyrosine residue to alpha-tubulin in the tubulin tyrosination cycle, is involved in tumor progression and has a vital role in neuronal organization. We show that in mammalian fibroblasts, CLIP-170, and other microtubule tip tracking proteins comprising a CAP-Gly microtubule-binding domain such as CLIP-115 and...
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ژورنال
عنوان ژورنال: BMC Plant Biology
سال: 2017
ISSN: 1471-2229
DOI: 10.1186/s12870-017-0987-5